Key words: eugenol, isoeugenol, chalcone, aldol condensation, oxidative
cyclization
By: Tri Redjeki, Elfi Susanti VH
Synthesis of flavone and its derivatives is mostly done by direct isolation of the flavonoids from natural ingredients and it takes a lot less profitable plants to get it, so that synthesis is the best alternative to obtain large amounts of flavonoids. Besides, the synthesis of flavone and its derivatives nbso attract attention associated with the activity of biocides, farmasetikal and antioxidants. As a basic material for the synthesis of flavonoids can be used eugenol, clove oil obtained from the available abundant in nature. Eugenol converted into isoeugenol, followed by oxidation of isoeugenol into vanillin. Then, Vanillin methylated into veratraldehid. Aldol condensation reaction of 2.4 dihydroxyacetophenon with veratraldehyde produce 2 “, 4”-dihydroxy 3,4-dimethoxychalcone. This synthesis products will be changed to flavone. The compounds formed were characterized by spectroscopy (UV-Vis, IR, NMR and MS).